Anagrelide HCl

CAT: 0421-27732-2Size: 50 mgDry Ice: NoHazardous: No
CAT#:0421-27732-2Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation. Anagrelide selectively affects thrombocytes while shows no significant effect on white blood cells, erythrocytes, or coagulation. Anagrelide is a potent inotropic agent for dogs with remarkable vasodilatory activity. Additionally, anagrelide can reduce renal blood flow. Furthermore, anagrelide has shown to play roles in other chronic myeloproliferative disorders, such as polycythemia vera, chronic myeloid leukemia and agnogenic myeloid metaplasia. Anagrelide has some side effects involving headache, diarrhea, edema, palpitations, and abdominal pain.
Description
Anagrelide is a selective thrombocytopenic agent that inhibits PDE3. It also has been used in the treatment of chronic myeloid leukemia.
CAS Number
58579-51-4
Purity
≥ 98%
Format
Solid
Solubility
Insoluble in EtOH; insoluble in H2O; ≥ 4.9 mg/mL in DMSO. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Long-term storage in solution is not recommended. Not stable in diluted solutions.
Molecular Formula
C10H8Cl3N3O
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
At least 6 months at -20°C.
Calculated Molecular Weight
292.55 Da

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