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Bendamustine HCl

CAT: 0421-27738-1Size: 25 mgDry Ice: NoHazardous: No
CAT#:0421-27738-1Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Bendamustine inhibits mitotic checkpoints and induces mitotic catastrophe by inhibiting several mitosis-related genes such as Polo-like kinase 1, Aurora kinase A, and Cyclin B1. In myeloma cell lines, bendamustine induced apoptosis by cleavage of caspase 3, and resulted in G2 cell cycle arrest. In chronic lymphocytic and mantle cell lymphoma cell lines, bendamustine HCl has been shown to activate both the mitochondrial cell death pathway and caspase-dependent apoptosis.
Description
Bendamustine HCl is an alkylating agent associated with DNA damage (IC50 = 50 µM) . It is a cytostatic agent that displays activity in non-Hodgkin's lymphomas.
CAS Number
3543-75-7
Solubility
Soluble in DMSO
Molecular Formula
C16H21Cl2N3O2•HCl
Shipping Conditions
Room Temperature (continental US) or Gel Packs
Storage Conditions
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Calculated Molecular Weight
394.7 Da

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sc-357294Bendamustine
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