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Fluorogenic SHP1 (PTPN6) Assay Kit

CAT: 0421-79831Size: 96 ReactionsDry Ice: YesHazardous: No
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CAT#:0421-79831Size:96 Reactions
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SHP1 (also known as PTPN6) is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine-stimulated cells. The noncatalytic N-terminus of this phosphatase can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 is involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating molecules related to the MAP kinase pathway.
Description
The Fluorogenic SHP1 Assay Kit is designed to measure SHP1 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps. The SHP1 assay kit comes in a convenient 96-well format, with purified SHP1 enzyme, fluorogenic substrate, and PTP assay buffer for 100 enzyme reactions. This kit is developed to identify inhibitors of the regulatory region of SHP1.Need us to run inhibitor screens or profile your compounds against SHP1 (PTPN6) ? Check out ourProtein Tyrosine Phosphatase Screening Services.
UniProt
P29350
Applications
Great for studying enzyme kinetics and HTS applications.
Format
Catalog #ComponentAmountStorage100342Recombinant Human SHP1 (221-523) ≥1 µg-80°CAvoidfreeze/thaw cycles!0.5 mM PTP Substrate (DiFMUP) 50 µl-80°C797165X PTP Assay Buffer3 ml-20°C0.5 M DTT200 µl-20°C79685Black, low binding black microtiter plate1RoomTemp
Shipping Conditions
-80°C
Storage Conditions
6 months from date of receipt when stored as directed.

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