MMP7 Fluorogenic Assay Kit

• Background:

  MMP7 (also known as matrix metalloproteinase 7 or pump-1 protease) is a member of the large family of matrix metalloproteinases (MMP) responsible for the breakdown of extracellular matrix proteins such as casein, collagen, and fibronectin. Most MMPs are secreted as inactive pro-proteins and are activated when cleaved by other extracellular proteinases. MMP7 cleaves fibronectin, gelatin and elastin, but not collagen. MMPs are involved in tissue remodeling and in the escape of metastatic cells from the primary tumor and angiogenesis. MMP7 can activate MMP2 and MMP9, and upregulation of MMP7 is found in many carcinomas. They are candidate therapeutic targets in various diseases related to tissue remodeling including cancer and inflammatory diseases.

• Description:

  The MMP7 (Matrix MetalloProteinase 7) Fluorogenic Assay Kit is designed to measure MMP7 protease activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.Need us to run inhibitor screens or profile your compounds against MMP7? Check out ourProtease Screening Services.

• UniProt:

  P09237

• Applications:

  Screen or profile small molecule inhibitors of MMP7.

• Format:

  Catalog #NameAmountStorageRecombinant MMP7*7.5 µg-80°C799191 mM MMP Substrate10 µl-80°C79917MMP Assay Buffer 125 ml-20°C79685Black 96-well plate1Room Temp*The concentration of the protein is lot-specific and will be indicated on the tube.

• Shipping Conditions:

  -80°C

• Storage Conditions:

  This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.

• Notes:

  Troubleshooting GuideVisitbpsbioscience.com/assay-kits-faqfor detailed troubleshooting instructions. For further questions, please email[email protected]

• Contraindications:

  The final concentration of DMSO in the assay should not exceed 1%.