Tolcapone-d7

• UNSPSC Description:

  Tolcapone-d7 is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].

• Target Antigen:

  Amyloid-β; COMT; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease;Neuronal Signaling;Others

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=C([2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C2[2H]

• Molecular Weight:

  280.28

• References & Citations:

  [1]Paterson NE, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci Res. 2011 Jan;69(1):41-50.|[2]Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):14941-54.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported