Thiorphan-d7

CAT: 0804-HY-W013375S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W013375S-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thiorphan-d7 is the deuterium labeled Thiorphan[1]. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[2].
CAS Number
[1276297-68-7]
UNSPSC
12352005
Target
Neprilysin
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
OC(CNC(C(CS)C([2H])([2H])C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O)=O
Molecular Formula
C12H8D7NO3S
Molecular Weight
260.36
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582 (16) :2382-6.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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