Tolcapone (Standard)

CAT: 0804-HY-17406R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17406R-01Size:5 mg
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Description
Tolcapone (Standard) (Ro 40-7592 (Standard) ) is the analytical standard of Tolcapone (HY-17406) . Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma[1][2][3][4].
CAS Number
[134308-13-7]
Product Name Alternative
Ro 40-7592 (Standard)
UNSPSC
12352005
Target
Amyloid-β; Apoptosis; COMT; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tolcapone-standard.html
Smiles
O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=CC=C(C)C=C2
Molecular Formula
C14H11NO5
Molecular Weight
273.24
References & Citations
[1]De Santi C, et al. Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone. Eur J Clin Pharmacol. 1998 May;54 (3) :215-9.|[2]Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285 (20) :14941-14954. |[3]Ceravolo R, et al. 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease. Synapse. 2002 Mar 1;43 (3) :201-7.|[4]Maser T, et al. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma. Cancer Med. 2017 Jun;6 (6) :1341-1352.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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