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DNMT3A antibody

CAT: 0710-FNab10773Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10773Size:100 µg
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Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Synonyms
DNA (cytosine-5) -methyltransferase 3A (Dnmt3a) |Cysteine methyltransferase DNMT3A|DNA methyltransferase HsaIIIA (DNA MTase HsaIIIA, M.HsaIIIA) |DNMT3A
Gene ID
1788
UniProt
Q9Y6K1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
DNA (cytosine-5-) -methyltransferase 3 alpha
Target
DNMT3A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC

UniProtKB · Q9Y6K1

DNA (cytosine-5)-methyltransferase 3A

DNM3A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6K1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DNMT3A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Dnmt3a
EC number
2.1.1.37
Processing
—
Secondary accessions
E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageAlternative splicing

Molecular function

Chromatin regulatorDNA-bindingMethyltransferaseRepressorTransferase

Cellular component

ChromosomeCytoplasmNucleus

Disease

Disease variantDwarfismIntellectual disability

PTM

Isopeptide bondMethylationPhosphoproteinUbl conjugation

Ligand

Metal-bindingS-adenosyl-L-methionineZinc

Domain

Zinc-finger

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