DNMT1 antibody

CAT: 0710-FNab10776Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab10776Size:100 µg

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Background

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306) . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306) . Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306) . Promotes tumor growth (PubMed:24623306) .

Synonyms

Gene ID

1786

UniProt

P26358

Host

Rabbit

Reactivity

Human

Immunogen

DNA (cytosine-5-) -methyltransferase 1

Target

DNMT1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC

Field of Research

Epigenetics, Metabolism

Purification

Immunogen affinity purified

Dilution

IHC: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, IHC

UniProtKB · P26358

DNA (cytosine-5)-methyltransferase 1

DNMT1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P26358
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: DNMT1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Dnmt1
EC number: 2.1.1.37
Processing: —
Secondary accessions: A0AV63, B7ZLW6, Q9UHG5, Q9ULA2, Q9UMZ6

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorChromatin regulatorDNA-bindingMethyltransferaseRepressorTransferase

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeNucleus

Disease

DeafnessDisease variantNeuropathy

Ligand

Metal-bindingS-adenosyl-L-methionineZinc

Domain

RepeatZinc-finger

Biological process

TranscriptionTranscription regulation

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