DNMT1 antibody

CAT: 0710-FNab02482Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab02482Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306) . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306) . Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306) . Promotes tumor growth (PubMed:24623306) .
Synonyms
DNA (cytosine-5) -methyltransferase 1 (Dnmt1) |CXXC-type zinc finger protein 9|DNA methyltransferase HsaI (DNA MTase HsaI, M.HsaI) |MCMT|DNMT1|AIM|CXXC9|DNMT
Gene ID
1786
UniProt
P26358
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
DNA (cytosine-5-) -methyltransferase 1
Target
DNMT1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IP, WB, IF
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
180-200 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IP, WB, IF

Related Products

CatalogName
EM2103Mouse DNMT1 (DNA (cytosine-5) -methyltransferase 1) ELISA Kit
EH2103Human DNMT1 (DNA (cytosine-5) -methyltransferase 1) ELISA Kit
FNab02576DNM1 antibody
EM0991Mouse DNM1 (Dynamin 1) ELISA Kit
EH2022Human DNM1 (Dynamin-1) ELISA Kit
FNab11062CA125 antibody (capture antibody)
FNab11060AFP antibody (capture antibody)
FNab11045-01CEA antibody (detection antibody)
FNab11059AFP antibody (detection antibody)
FNab11061CA125 antibody (detection antibody)

Alternative Products

CatalogName
C42013-01DNMT1 Antibody

Popular Products