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P16INK4a Antibody / CDKN2A

CAT: 0800-V8694-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8694-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P16INK4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. Expression of p16INK4a (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinomas (HNSCC) . p16 status is an important prognostic indicator in HNSCC and the p16 positive/HPV16 negative group is likely a distinct subgroup lacking any HPV genotype.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P42771
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the p16INK4a antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
CDKN2A/3830
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the p16INK4a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This p16INK4a antibody is available for research use only.
Storage Conditions
Store the p16INK4a antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the p16INK4a antibody should be determined by the researcher.
Location
Nuclear and cytoplasmic
Image Legend
IHC staining of FFPE human cervix with p16INK4a antibody (clone CDKN2A/3830) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P42771

Cyclin-dependent kinase inhibitor 2A

CDN2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42771
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDKN2A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A5X2G7, D3DRK1, G3XAG3, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Biological process

Cell cycle

Cellular component

CytoplasmNucleus

Disease

Disease variantLi-Fraumeni syndromeTumor suppressor

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