Products for Research Use Only
RegisterLogin

CDKN2A Antibody / p16INK4a

CAT: 0800-V9523-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V9523-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
P16INK4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. Expression of p16INK4a (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinomas (HNSCC) . p16 status is an important prognostic indicator in HNSCC and the p16 positive/HPV16 negative group is likely a distinct subgroup lacking any HPV genotype.
CAS Number
9000-83-3
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P42771
Host
Mouse
Reactivity
Human
Immunogen
Purified recombinant prokaryotic full-length human p16INK4a protein was used as the immunogen for the CDKN2A antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2a κ
Clone
RCDKN2A/4845
Type
Recombinant
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CDKN2A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CDKN2A antibody is available for research use only.
Storage Conditions
Aliquot the CDKN2A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CDKN2A antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
Western blot testing of human HepG2 cell lysate using CDKN2A antibody (clone rCDKN2A/4845) . Predicted molecular weight ~16 kDa.

UniProtKB · P42771

Cyclin-dependent kinase inhibitor 2A

CDN2A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42771
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDKN2A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A5X2G7, D3DRK1, G3XAG3, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Biological process

Cell cycle

Cellular component

CytoplasmNucleus

Disease

Disease variantLi-Fraumeni syndromeTumor suppressor

Related Products

CatalogName
V8604SAF-100UGP16INK4a Antibody / CDKN2A
V8604-100UGP16INK4a Antibody / CDKN2A
V8694SAF-100UGP16INK4a Antibody / CDKN2A
V5278-20UGP16INK4a Antibody / CDKN2A
V8694-100UGP16INK4a Antibody / CDKN2A
V5279-100UGP16INK4a Antibody / CDKN2A
V5278-100UGP16INK4a Antibody / CDKN2A
V5280-20UGP16INK4a Antibody / CDKN2A
V5280-100UGP16INK4a Antibody / CDKN2A
V5279SAF-100UGP16INK4a Antibody / CDKN2A

Alternative Products

CatalogName
8975-01CDKN2A/p16INK4a Antibody
GTR18316552CDKN2A Antibody / p16INK4a
13-896CDKN2A / p16INK4a Antibody
GTR18226312P16INK4a/CDKN2A Antibody
bs-4592R-TRCDKN2A/p16INK4a Polyclonal Antibody
27527-01CDKN2A / p16INK4a Polyclonal Antibody
APR02292GPolyclonal CDKN2A / p16INK4a Antibody
C20927-50uLCDKN2A/p16INK4a Antibody [B12M16]
E8ER1803-53CDKN2A/p16INK4a
8975PCDKN2A/p16INK4a Peptide

Popular Products