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Recombinant Bcl6 Antibody

CAT: 0800-V8064SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8064SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) . The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P41182
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 256-389) was used as the immunogen for this recombinant Bcl6 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
BCL6/2497R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant Bcl6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Bcl6 antibody is available for research use only.
Storage Conditions
Store the recombinant Bcl6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant Bcl6 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC staining of FFPE human tonsil with recombinant Bcl6 antibody (clone BCL6/2497R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P41182

B-cell lymphoma 6 protein

BCL6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P41182
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BCL6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BCL-6
EC number
—
Processing
—
Secondary accessions
A7E241, B8PSA7, D3DNV5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ImmunityInflammatory responseTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Disease

Proto-oncogene

Domain

RepeatZinc-finger
Product Datasheet
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