Recombinant BCL6 Monoclonal Antibody

• Background:

  Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

• Abbreviation:

  BCL6

• UniProt:

  P41182

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human BCL6 fragment

• Target:

  ZNF; LAZ; ZBTB; BCL; BCL6; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A139

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Epigenetics and Nuclear Signaling; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-1:5000; IHC 1:100-1:500

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  79 kDa

• Observed Molecular Weight:

  78 kDa

• Isotype:

  IgG, κ