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PDCD1 Antibody / PD-1 / PD1

CAT: 0800-V7574-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7574-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q15116
Host
Mouse
Reactivity
Human
Immunogen
Human full-length recombinant PDCD1 protein was used as the immunogen for the PDCD1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
PDCD1/2720
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PDCD1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PDCD1 antibody is available for research use only.
Storage Conditions
Store the PDCD1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface, cytoplasmic
Image Legend
IHC staining of FFPE human tonsil with PDCD1 antibody (clone PDCD1/2720) . HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · Q15116

Programmed cell death protein 1

PDCD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15116
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDCD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein PD-1, hPD-1
EC number
—
Processing
Precursor
Secondary accessions
O00517, Q8IX89
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityApoptosisImmunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

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