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PD1 Antibody / PDCD1

CAT: 0800-V4967SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4967SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
CAS Number
9000-83-3
Specifications
ELISA (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q15116
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment corresponding to the extracellular domain of human PDCD1 protein was used as the immunogen for the PD1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
PDCD1/7276R
Type
Recombinant
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the PD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PD1 antibody is available for research use only.
Storage Conditions
Aliquot the PD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the PD1 antibody should be determined by the researcher.
Location
Cell surface, Cytoplasm
Image Legend
IHC staining of FFPE human tonsil tissue with PD1 (CD279) antibody (clone PDCD1/7276R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q15116

Programmed cell death protein 1

PDCD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15116
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDCD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein PD-1, hPD-1
EC number
—
Processing
Precursor
Secondary accessions
O00517, Q8IX89
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityApoptosisImmunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix
Product Datasheet
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