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CD47 Antibody / IAP

CAT: 0800-V7184IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7184IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q08722
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 18-135 from the human protein were used as the immunogen for the CD47 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CDLA47-1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the CD47 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD47 antibody is available for research use only.
Storage Conditions
Store the CD47 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Applications Notes
Optimal dilution of the CD47 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Location
Cell surface, cytoplasmic
Image Legend
IHC staining of FFPE human prostate carcinoma with CD47 antibody (clone CDLA47-1) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

UniProtKB · Q08722

Leukocyte surface antigen CD47

CD47_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q08722
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD47
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K198, D3DN59, Q53Y71, Q96A60
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisApoptosisCell adhesionInflammatory response

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoproteinPyrrolidone carboxylic acid

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

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