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HER2 Antibody

CAT: 0800-V7074-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7074-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HER2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. HER2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary. [RefSeq]
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells in 0.1ml, Immunofluorescence: 1-4 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this HER2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
2KRI7
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the HER2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This HER2 antibody is available for research use only.
Storage Conditions
Store the HER2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the HER2 antibody to be titered up or down for optimal performance.
Location
Cell surface
Image Legend
Immunofluorescent staining of human MCF7 cells with HER2 antibody (clone 2KRI7, green) and Reddot nuclear stain (red) .
Product Datasheet
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