ErbB2 Antibody / HER2

CAT: 0800-V3835-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V3835-100UGSize:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
HER2/ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary. [RefSeq]
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P04626
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 311-462 from the human protein was used as the immunogen for this ErbB2 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
2KRI7-2
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the ErbB2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This ErbB2 antibody is available for research use only.
Storage Conditions
Store the ErbB2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the ErbB2 antibody to be titered up or down for optimal performance.
Location
Cell membrane (This mAb binds to the extracellular/cell surface region of the protein)
Image Legend
IHC testing of FFPE human breast carcinoma with ErbB2 antibody (clone 2KRI7-2) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Product Datasheet
Loading...

Related Products

CatalogName
RQ5055HER2 Antibody / ErbB2
V7407-100UGHER2 Antibody / ErbB2
V2108SAF-100UGHER2 Antibody / ErbB2
V7735-100UGHER2 Antibody / ErbB2
V2378SAF-100UGHER2 Antibody ErbB2
V2111SAF-100UGHER2 ErbB2 Antibody
V2110-100UGHER2 ErbB2 Antibody
V7736-20UGHER2 Antibody / ErbB2
V2110-20UGHER2 ErbB2 Antibody
V2108-100UGHER2 Antibody / ErbB2

Alternative Products

CatalogName
MBS9610969-01HER2/ErbB2 Antibody
OASL01190-50ULERBB2 (HER2) Antibody
71-230ERBB2 / HER2 Antibody
abx233835HER2 / ErbB2 Antibody
MBS9433538-01HER2/ErbB2 Polyclonal Antibody
APR00196GPolyclonal HER2/ErbB2 Antibody
MBS8533562-01HER2/ErbB2
E8ER0106HER2 / ErbB2

Popular Products