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Recombinant TIMP1 Antibody

CAT: 0800-V3596-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3596-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, and pregnancy.

The dysregulated activity of TIMP1 has been implicated in cancer. In pregnancy, TIMP1 plays a regulatory role in the process of implantation, particularly the cytotrophoblast invasion of the uterine endometrium. Additionally, it plays a role in regulating the transcriptional profile of fetal and placental tissues associated with the early stages of pregnancy. Studies attribute this role to a mechanism involving the chromatin structure at the TIMP1 promoter region, implicating new pharmaceutical possibilities for the therapeutic regulation of TIMP1. Accordingly, TIMP1 can be manipulated in vitro using techniques, like the TIMP1 knock-out. [Wiki]
CAS Number
9000-83-3
Specifications
ELISA: 2-4 µg/mL (order BSA/azide-free format)
UniProt
P01033
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this recombinant TIMP1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
TIMP1/1944R
Type
Recombinant
Applications
ELISA
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the recombinant TIMP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant TIMP1 antibody is available for research use only.
Storage Conditions
Store the recombinant TIMP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic, secreted
Image Legend
SDS-PAGE analysis of purified, BSA-free recombinant TIMP1 antibody (clone TIMP1/1944) as confirmation of integrity and purity.

UniProtKB · P01033

Metalloproteinase inhibitor 1

TIMP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01033
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TIMP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q14252, Q9UCU1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Growth factorMetalloenzyme inhibitorMetalloprotease inhibitorProtease inhibitor

Ligand

Metal-bindingZinc

Cellular component

Secreted

Domain

Signal

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