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MRP1 Antibody / ABCC1

CAT: 0800-V3529SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3529SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL
UniProt
P33527
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant full-length protein was used as the immunogen for this MRP1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
MRP1/1344
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the MRP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MRP1 antibody is available for research use only.
Storage Conditions
Store the MRP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MRP1 antibody to be titered up or down for optimal performance.
Location
Cytoplasmic and cell surface
Image Legend
SDS-PAGE Analysis of Purified, BSA-Free MRP1 Antibody (clone MRP1/1344) . Confirmation of Integrity and Purity of the Antibody.

UniProtKB · P33527

ATP-binding cassette sub-family C member 1

MRP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P33527
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ABCC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
7.6.2.-
Processing
—
Secondary accessions
A3RJX2, C9JPJ4, O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99, Q9UQA0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

Disease

DeafnessNon-syndromic deafness

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

HydrolaseTranslocase

Biological process

Lipid transportTransport

Domain

RepeatTransmembraneTransmembrane helix

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