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MRP1 Antibody

CAT: 0800-R30717Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30717Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABCC1 (ATP-binding cassette, subfamily C, member 1), also called MRP1, is a protein that in humans is encoded by the ABCC1 gene. ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. It is a plasma membrane drug-efflux pump.The gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1/MRP1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking MRP1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that it is an important protector in this scenario. The protein clears beta-amyloid from brains of mice and can be activated by thiethylperazine. And Chemotaxis assays show that MPR1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P33527
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids LLQQRGLFYSMAKDAGLV (human) were used as the immunogen for this MRP1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MRP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MRP1 antibody is available for research use only.
Storage Conditions
After reconstitution, the MRP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MRP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic and cell surface
Image Legend
Western blot testing of MRP1 antibody and Lane 1: Jurkat; 2: CEM; 3: A549 lysate. Predicted molecular weight: 152-172 kDa (multiple isoforms), can be observed at ~190 kDa.

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