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MRP3 Antibody / ABCC3

CAT: 0800-V8183-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V8183-20UGSize:20 µg
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Description
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps exp- ressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also medi- ates the transport of the organic anion S- (2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
O15438
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human protein fragment (amino acids 815-957) was used as the immunogen for this MRP3 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
ABCC3/2971
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the MRP3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MRP3 antibody is available for research use only.
Storage Conditions
Store the MRP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the MRP3 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
IHC staining of FFPE human pancreatic carcinoma with MRP3 antibody (clone ABCC3/2971) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · O15438

ATP-binding cassette sub-family C member 3

MRP3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15438
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ABCC3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
7.6.2.-, 7.6.2.2, 7.6.2.3
Processing
—
Secondary accessions
B2RPA9, D3DTX9, O60265, O60922, O75621, O95078, O95289, O95290, Q86X85, Q9UN52
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

PTM

GlycoproteinPhosphoprotein

Biological process

Lipid transportTransport

Domain

RepeatTransmembraneTransmembrane helix

Molecular function

Translocase
Product Datasheet
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