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TSHR Antibody (alpha chain)

CAT: 0800-V3444-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3444-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P16473
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM223
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the TSHR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TSHR antibody is available for research use only.
Storage Conditions
Store the TSHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TSHR antibody to be titered up or down for optimal performance.
Location
Cytoplasmic, cell surface
Image Legend
IHC testing of FFPE human thyroid carcinoma with TSHR antibody (clone SPM223) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, or 10mM citrate buffer, pH 6, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P16473

Thyrotropin receptor

TSHR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16473
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TSHR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0A0A0MTJ0, A0PJU7, F5GYU5, G3V2A9, Q16503, Q8TB90, Q96GT6, Q9P1V4, Q9ULA3, Q9UPH3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Disease

Congenital hypothyroidismDisease variant

PTM

Disulfide bondGlycoproteinSulfation

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

Leucine-rich repeatRepeatSignalTransmembraneTransmembrane helix

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