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Mucin-3 Antibody

CAT: 0800-V2730IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2730IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3) . Its epitope localizes between amino acids SITTTE. This mAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3) . The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q02505
Host
Mouse
Reactivity
Human
Immunogen
Amino acids (C-HSTPSFTSSITTTETTSHSTPSFTSSITTTETTS) which contains two of the MUC3 tandem repeats was used as the immunogen for the Mucin-3 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
M3.1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Mucin-3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Mucin-3 antibody is available for research use only.
Storage Conditions
Store the Mucin-3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic and cell surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human colon carcinoma stained with Mucin-3 antibody (M3.1) .

UniProtKB · Q02505

Mucin-3A

MUC3A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q02505
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUC3A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MUC-3A
EC number
—
Processing
Precursor
Secondary accessions
A6NP22, O14650, O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

MembraneSecreted

Technical term

Proteomics identificationReference proteome

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