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Mucin-1 Antibody

CAT: 0800-V9048SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9048SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mucin-1 is a 265-400kDa glycoprotein. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit and the C-terminal beta subunit. . The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. MUC1 may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P15941
Host
Mouse
Reactivity
Human
Immunogen
Delipidated extract of human milk fat globule membranes was used as the immunogen for this Mucin-1 antibody.
Clonality
Monoclonal
Isotype
IgG2a λ
Clone
SPM533
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Mucin-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Mucin-1 antibody is available for research use only.
Storage Conditions
Store the Mucin-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cytoplasmic & cell surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human breast carcinoma stained with Mucin-1 antibody (clone SPM533) .

UniProtKB · P15941

Mucin-1

MUC1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15941
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MUC-1
EC number
—
Processing
Precursor
Secondary accessions
A5YRV1, A6ZID9, A6ZIE0, B1AVQ8, B1AVR0, B6ECA1, E7ESE5, E7EUG9, P13931, P15942, P17626, Q0VAP5, Q0VAP6, Q14128, Q14876, Q16437, Q16442, Q16615, Q6S4Y3, Q7Z547, Q7Z548, Q7Z550, Q7Z552, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Cellular component

Cell membraneCytoplasmMembraneNucleusSecreted

Domain

RepeatSignalTransmembraneTransmembrane helix

Disease

Tumor suppressor
Product Datasheet
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