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MS4A1 Antibody / CD20

CAT: 0800-RQ6739Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6739Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD20, also known as MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. It is mapped to 11q12.2. This gene encodes a member of the membrane-spanning 4A gene family. The function of CD20 is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that CD20 acts as a calcium channel in the cell membrane. What�s more, this protein may be involved in the regulation of B-cell activation and proliferation.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunofluorescence (FFPE) : 5 µg/mL
UniProt
P11836
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein (amino acids M1-P297) was used as the immunogen for the MS4A1 antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
4I11
Applications
WB, IF
Purity
Affinity purified
Format
Purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the MS4A1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MS4A1 antibody is available for research use only.
Storage Conditions
After reconstitution, the MS4A1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MS4A1 antibody should be determined by the researcher.
Location
Predominantly cell surface with some cytoplasmic
Image Legend
Immunofluorescent staining of FFPE human tonsil tissue with MS4A1 antibody (red) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P11836

B-lymphocyte antigen CD20

CD20_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11836
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MS4A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NMS4, B4DT24, P08984, Q13963
Protein keywords

Technical term

3D-structurePharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

B-cell activation

Cellular component

Cell membraneMembrane

PTM

Disulfide bondLipoproteinPalmitatePhosphoprotein

Domain

TransmembraneTransmembrane helix

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