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Synaptophysin Antibody / SYP

CAT: 0800-RQ6706Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6706Size:100 µg
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Description
Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. It is mapped to Xp11.23. This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence (FFPE) : 5 µg/mL
UniProt
P08247
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids DLSIEVEFEYPFRLHQVYFDAPTCR from the human protein were used as the immunogen for the Synaptophysin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Synaptophysin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Synaptophysin antibody is available for research use only.
Storage Conditions
After reconstitution, the Synaptophysin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Synaptophysin antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Immunofluorescent staining of FFPE mouse brain tissue with Synaptophysin antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · P08247

Synaptophysin

SYPH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08247
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SYP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R7L6, B7Z359, Q6P2F7
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

Calcium

Cellular component

Cytoplasmic vesicleMembraneSynapseSynaptosome

Disease

Disease variantIntellectual disability

PTM

GlycoproteinPhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix

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