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IRAK1 Antibody

CAT: 0800-RQ5587Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5587Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin-1 receptor-associated kinase 1, also called IRAK1, is an enzyme that in humans is encoded by the IRAK1 gene. By radiation hybrid analysis, this gene is mapped to chromosome Xq28. Serine/threonine-protein kinase plays a critical role in initiating innate immune response against foreign pathogens. This gene involved in Toll-like receptor (TLR) and IL-1R signaling pathways. This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.
CAS Number
9007-83-4
Specifications
Western blot: 0.25-0.5 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Immunofluorescence: 2-4 µg/mL
UniProt
P51617
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids NRNARVADLVHILTHLQLLRARD were used as the immunogen for the IRAK1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS, IF
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the IRAK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This IRAK1 antibody is available for research use only.
Storage Conditions
After reconstitution, the IRAK1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the IRAK1 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human ovarian cancer with IRAK1 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 20 min and allow to cool before testing.

UniProtKB · P51617

Interleukin-1 receptor-associated kinase 1

IRAK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51617
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IRAK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IRAK-1
EC number
2.7.11.1
Processing
—
Secondary accessions
D3DWW3, D3DWW4, Q7Z5V4, Q96C06, Q96RL2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumNucleotide-binding

Cellular component

CytoplasmLipid dropletNucleus

Biological process

Host-virus interactionImmunityInnate immunity

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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