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IRAKM Antibody

CAT: 0800-R31330Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31330Size:100 µg
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Description
Interleukin-1 receptor-associated kinase 3, also called IRAK3 or IRAKM is an enzyme that in humans is encoded by the IRAK3 gene. The IRAKM gene consists of 12 exons spanning a region of approximately 60 kb in chromosome 12q14.3. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q9Y616
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the C-terminus of human IRAKM (WFPKYIVPSQDLRPYKVNID) was used as the immunogen for this IRAKM antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the IRAKM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This IRAKM antibody is available for research use only.
Storage Conditions
After reconstitution, the IRAKM antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the IRAKM antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of IRAKM antibody and Lane 1: HeLa; 2: Jurkat; 3: HUT102 cell lysate. Predicted molecular weight: ~68kDa.

UniProtKB · Q9Y616

Interleukin-1 receptor-associated kinase 3

IRAK3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y616
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IRAK3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IRAK-3
EC number
—
Processing
—
Secondary accessions
B4DQ57
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Asthma

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

PTM

Disulfide bondPhosphoprotein

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