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IRAK4 Antibody

CAT: 0800-F42537-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F42537-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q9NWZ3
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 25-52 from the human protein was used as the immunogen for this IRAK4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the IRAK4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IRAK4 antibody is available for research use only.
Storage Conditions
Aliquot the IRAK4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the IRAK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Bovine
Image Legend
IRAK4 antibody western blot analysis in NCI-H460 lysate. Predicted molecular weight 52/37 kDa (isoforms 1/2) .

UniProtKB · Q9NWZ3

Interleukin-1 receptor-associated kinase 4

IRAK4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NWZ3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IRAK4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IRAK-4
EC number
2.7.11.1
Processing
—
Secondary accessions
Q69FE1, Q8TDF7, Q9Y589
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumNucleotide-binding

Cellular component

Cytoplasm

Disease

Disease variant

Biological process

ImmunityInnate immunity

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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