CDK4 Antibody

• Description :

  The protein encoded by the CDK4 gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [RefSeq]

• Specifications :

  Western blot: 1:1000-1:2000

• UniProt :

  P11802

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide specific to human CDK4 was used as the immunogen for the CDK4 antibody.

• Clonality :

  Monoclonal

• Isotype :

  IgG

• Clone :

  HOB-3

• Type :

  Recombinant

• Applications :

  WB

• Purity :

  Affinity purified

• Format :

  Purified

• Buffer :

  Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA

• Reconstitution :

  Store the CDK4 antibody at -20oC.

• Limitations :

  This CDK4 antibody is available for research use only.

• Storage Conditions :

  Store the CDK4 antibody at -20°C.

• Formulation :

  Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

• Applications Notes :

  Optimal dilution of the CDK4 antibody should be determined by the researcher.

• CAS Number :

  9000-83-3

• Image Legend :

  Western blot testing of human HeLa cell lysate with CDK4 antibody. Predicted molecular weight ~34 kDa.