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CD11b Antibody / MAC-1

CAT: 0800-V4403-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V4403-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P11215
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 900-1100) from the human protein was used as the immunogen for the CD11b antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
ITGAM/4741
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CD11b antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD11b antibody is available for research use only.
Storage Conditions
Aliquot the CD11b antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD11b antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
IHC staining of FFPE human spleen tissue with CD11b antibody (clone ITGAM/4741) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P11215

Integrin alpha-M

ITAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11215
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q4VAK0, Q4VAK1, Q4VAK2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesionImmunityInnate immunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Disease

Systemic lupus erythematosus

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