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Raf1 Antibody / c-Raf

CAT: 0800-RQ5032Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5032Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) . [UniProt]
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000
UniProt
P04049
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Raf1 was used as the immunogen for the Raf1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
BEC-18
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Raf1 antibody at -20oC.
Limitations
This Raf1 antibody is available for research use only.
Storage Conditions
Store the Raf1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Raf1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human K562 cell lysate with Raf1 antibody. Predicted molecular weight ~73 kDa.

UniProtKB · P04049

RAF proto-oncogene serine/threonine-protein kinase

RAF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04049
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RAF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
B0LPH8, B2R5N3, Q15278, Q9UC20
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Disease

CardiomyopathyDeafnessDisease variantProto-oncogene

Cellular component

Cell membraneCytoplasmMembraneMitochondrionNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

MethylationPhosphoprotein

Domain

Zinc-finger

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