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SIRT4 Antibody

CAT: 0800-RQ4960Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4960Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sirtuin 4, also known as SIRT4, is a protein which in humans is encoded by the SIRT4 gene. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q9Y6E7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids HLKPDVVFFGDTVNPDKVDFVHKRVKEAD from the human protein were used as the immunogen for the SIRT4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the SIRT4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SIRT4 antibody is available for research use only.
Storage Conditions
After reconstitution, the SIRT4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SIRT4 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) rat brain, 2) rat heart, 3) rat liver, 4) mouse brain, 5) mouse heart and 6) mouse liver lysate with SIRT4 antibody at 0.5ug/ml. Predicted molecular weight ~35 kDa.

UniProtKB · Q9Y6E7

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

SIR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6E7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIRT4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.313
Processing
Precursor
Secondary accessions
O43346, Q32M33
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

Biological process

DNA damage

Molecular function

GlycosyltransferaseNucleotidyltransferaseTransferase

Ligand

Metal-bindingNADZinc

Cellular component

Mitochondrion

Domain

Transit peptide

Disease

Tumor suppressor
Product Datasheet
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