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SIRT3 Antibody

CAT: 0800-F49519-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F49519-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q9NTG7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 250-279 from the human protein was used as the immunogen for this SIRT3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the SIRT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SIRT3 antibody is available for research use only.
Storage Conditions
Aliquot the SIRT3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the SIRT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from (1) 293 and (2) HepG2 cell line using SIRT3 antibody at 1:1000. Predicted size: 44/28 kDa (full/processed)

UniProtKB · Q9NTG7

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

SIR3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NTG7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIRT3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hSIRT3
EC number
2.3.1.286
Processing
Precursor
Secondary accessions
B7Z5U6, Q9Y6E8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

Metal-bindingNADZinc

Cellular component

Mitochondrion

Molecular function

Transferase

Domain

Transit peptide

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