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SIRT6 Antibody

CAT: 0800-F43446-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F43446-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity) .
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
Q8N6T7
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 276-305 from the human protein was used as the immunogen for this SIRT6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the SIRT6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SIRT6 antibody is available for research use only.
Storage Conditions
Aliquot the SIRT6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
SIRT6 antibody western blot analysis in K562 lysate.

UniProtKB · Q8N6T7

NAD-dependent protein deacylase sirtuin-6

SIR6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N6T7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIRT6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.-
Processing
—
Secondary accessions
B2RCD0, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

AcyltransferaseChromatin regulatorDevelopmental proteinDNA-bindingGlycosyltransferaseNucleotidyltransferaseRNA-bindingTransferase

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeEndoplasmic reticulumNucleusTelomere

Biological process

DNA damageDNA repair

Ligand

Metal-bindingNADZinc

Disease

Tumor suppressor

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