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Alpha-2-macroglobulin Antibody / A2M

CAT: 0800-RQ4853Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ4853Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P01023
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human A2M / Alpha 2 Macroglobulin was used as the immunogen for the Alpha-2-macroglobulin antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
ABAO-1
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Alpha-2-macroglobulin antibody at -20oC.
Limitations
This Alpha-2-macroglobulin antibody is available for research use only.
Storage Conditions
Store the Alpha-2-macroglobulin antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Alpha-2-macroglobulin antibody should be determined by the researcher.
Image Legend
Western blot testing of human plasma lysate with Alpha-2-macroglobulin antibody. Expected molecular weight: 163-200 kDa depending on the level of glycosylation.

UniProtKB · P01023

Alpha-2-macroglobulin

A2MG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01023
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
A2M
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Alpha-2-M
EC number
—
Processing
Precursor
Secondary accessions
Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Domain

Bait regionSignal

PTM

Disulfide bondGlycoproteinIsopeptide bondThioester bond

Molecular function

Protease inhibitorSerine protease inhibitor

Cellular component

Secreted
Product Datasheet
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