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A2M Antibody / Alpha-2-Macroglobulin

CAT: 0800-V8548SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8548SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P01023
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 604-748 from the human protein was used as the immunogen for the A2M antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
A2M/3623
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the A2M antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This A2M antibody is available for research use only.
Storage Conditions
Store the A2M antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the A2M antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human liver with A2M antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P01023

Alpha-2-macroglobulin

A2MG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01023
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
A2M
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Alpha-2-M
EC number
—
Processing
Precursor
Secondary accessions
Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Domain

Bait regionSignal

PTM

Disulfide bondGlycoproteinIsopeptide bondThioester bond

Molecular function

Protease inhibitorSerine protease inhibitor

Cellular component

Secreted
Product Datasheet
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