A2M Antibody / Alpha-2-Macroglobulin

A2M Antibody / Alpha-2-Macroglobulin

• Description: Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.
• CAS Number: 9007-83-4
• UniProt: P01023
• Host: Mouse
• Immunogen: A portion of amino acids 604-748 from the human protein was used as the immunogen for the A2M antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Store the A2M antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This A2M antibody is available for research use only.