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AKT2 Antibody

CAT: 0800-RQ4627Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4627Size:100 µg
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Description
AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. This gene is mapped to 19q13.2. AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunofluorescence (FFPE) : 2-4 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P31751
Host
Mouse
Reactivity
Human
Immunogen
Amino acids DRYDSLGLLELDQRTHFPQFSYSASIRE were used as the immunogen for the AKT2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
10C6
Applications
WB, IF, FACS
Purity
Protein G affinity
Format
Purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the AKT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This AKT2 antibody is available for research use only.
Storage Conditions
After reconstitution, the AKT2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the AKT2 antibody should be determined by the researcher.
Image Legend
Immunofluorescent staining of FFPE human MCF7 cells with AKT2 antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P31751

RAC-beta serine/threonine-protein kinase

AKT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31751
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AKT2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
B2RBD8, Q05BV0, Q0VAN0, Q0VAN1, Q68GC0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCarbohydrate metabolismGlucose metabolismGlycogen biosynthesisGlycogen metabolismSugar transportTranslation regulationTransport

Ligand

ATP-bindingManganeseMetal-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmEndosomeMembraneNucleus

Molecular function

Developmental proteinKinaseSerine/threonine-protein kinaseTransferase

Disease

Diabetes mellitusDisease variantProto-oncogene

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