AKT1 Antibody
CAT:
800-F50139-0.08ML
Size:
0.08 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
AKT1 Antibody
- Description: AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. It and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
- CAS Number: 9007-83-4
- UniProt: P31749
- Host: Rabbit
- Immunogen: A portion of amino acids 115-144 from the human protein was used as the immunogen for this AKT1 antibody.
- Clonality: Polyclonal
- Isotype: Ig
- Applications: IHC, WB, IF, FACS, ELISA
- Format: Antigen affinity purified
- Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
- Reconstitution: Store at 4oC for up to one month. For long term, aliquot the AKT1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
- Limitations: This AKT1 antibody is available for research use only.