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ITGB2 Antibody / CD18

CAT: 0800-RQ4511Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4511Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITGB2 (Integrin beta-2), also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. ITGB2 is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The ITGB2 gene is mapped to 21q22.3. The expression of CD18 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans lack of ITGB2 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although ITGB2 is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the 'inside-out' signaling pathways.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P05107
Host
Mouse
Reactivity
Human
Immunogen
Human CD18 recombinant protein (amino acids Q404-S769) was used as the immunogen for the ITGB2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
1A3/2A10
Applications
IHC-P, WB
Purity
Protein G affinity
Format
Purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the ITGB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ITGB2 antibody is available for research use only.
Storage Conditions
After reconstitution, the ITGB2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ITGB2 antibody should be determined by the researcher.
Location
Cell membrane, cytoplasm
Image Legend
IHC testing of FFPE human tonsil tissue with ITGB2 antibody at 2ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

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