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CD18 Antibody

CAT: 0800-R30705Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R30705Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITGB2 (Integrin beta 2), also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. ITGB2/CD18 is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated CD18. The ITGB2 gene is mapped to 21q22.3. The expression of CD18 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans, lack of ITGB2 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although ITGB2 is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the inside-out signaling pathways.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P05107
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human CD18 (LREYRRFEKEKLKSQWN) was used as the immunogen for this CD18 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CD18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD18 antibody is available for research use only.
Storage Conditions
After reconstitution, the CD18 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CD18 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CD18 antibody and Lane 1: Jurkat cell lysate ; 2: CEM; 3: HT1080; 4: SMMC-7721; 5: HeLa cell lysate. Predicted/observed molecular weight: 85~95 kDa depending on glycosylation level.

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