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Cyp17a1 Antibody

CAT: 0800-RQ4446Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4446Size:100 µg
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Description
Cytochrome P450 17A1, also called steroid 17-alpha-monooxygenase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL (recombinant mouse protein)
UniProt
P27786
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Mouse Cyp17a1 recombinant protein (amino acids Q80-R363) was used as the immunogen for the Cyp17a1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Cyp17a1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Cyp17a1 antibody is available for research use only.
Storage Conditions
After reconstitution, the Cyp17a1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Cyp17a1 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
IHC testing of FFPE mouse testis tissue with Cyp17a1 antibody at 2ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P27786

Steroid 17-alpha-hydroxylase/17,20 lyase

CP17A_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P27786
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Cyp17a1
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
1.14.14.19
Processing
—
Secondary accessions
—
Protein keywords

Cellular component

Endoplasmic reticulumMembraneMicrosome

Ligand

HemeIronMetal-binding

Biological process

Lipid metabolismSteroidogenesis

Molecular function

LyaseMonooxygenaseOxidoreductase

Technical term

Reference proteome

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