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CYP11A1 Antibody

CAT: 0800-R30784Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30784Size:100 µg
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Description
Cytochrome p450, family 11, subfamily A, polypeptide 1), also called P450SCC, P450C11A1 or CYP11A, is a mitochondrial enzyme associated with the conversion of cholesterol to pregnenolone. CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The gene is mapped on 15q24.1. Expression of the CYP11A1 gene may play a role in skin physiology and pathology and that cutaneous proopiomelanocortin activity may be autoregulated by a feedback mechanism involving glucocorticoids synthesized locally by Slominski et al. Using in vitro studies, CYP11A1 catalyzed the side-chain cleavage of 7-dehydrocholesterol to form 7-dehydropregnenolone. In addition, it catalyzed the metabolism of biologically inert vitamin D3, which is formed from 7-dehydrocholesterol, to form 2 hydroxylated products, 20-hydroxyvitamin D3 and 20, 22-dihydroxyvitamin D3. Mutations in the gene cause congenital adrenal insufficiency with partial or complete 46, XY sex reversal.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, IHC (Frozen) : 0.5-1 µg/mL
UniProt
P05108
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the C-terminus of human CYP11A1 (ISFTFWPFNQEATQQ) was used as the immunogen for this CYP11A1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the CYP11A1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CYP11A1 antibody is available for research use only.
Storage Conditions
After reconstitution, the CYP11A1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the CYP11A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of CYP11A1 antibody and human placenta tissue lysate. Expected molecular weight: 50-60 kDa.

UniProtKB · P05108

Cholesterol side-chain cleavage enzyme, mitochondrial

CP11A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05108
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP11A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.15.6
Processing
Precursor
Secondary accessions
A8K8D5, B3KPU8, G3XAD7, Q15081, Q16805, Q8N1A7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol metabolismLipid biosynthesisLipid metabolismSteroid biosynthesisSteroid metabolismSteroidogenesisSterol metabolism

Disease

Disease variant

Ligand

HemeIronMetal-binding

Cellular component

MembraneMitochondrionMitochondrion inner membrane

Molecular function

MonooxygenaseOxidoreductase

Domain

Transit peptide

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