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Angiogenin Antibody

CAT: 0800-R32581Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32581Size:100 µg
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Description
Angiogenin (ANG1), also known as Ribonuclease 5, is a small 123 amino acid protein that in humans is encoded by the ANG gene. The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells, ELISA: 0.1-0.5 µg/mL (human protein tested) ; request BSA-free format for coating
Gene ID
283
UniProt
P03950
Host
Rabbit
Reactivity
Human
Immunogen
A human recombinant protein corresponding to amino acids Q25-P147 was used as the immunogen for the Angiogenin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, IHC-P, FACS, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Angiogenin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Angiogenin antibody is available for research use only.
Storage Conditions
After reconstitution, the Angiogenin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Angiogenin antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear, secreted
Image Legend
Immunofluorescent staining of FFPE human U-2 OS cells with Angiogenin antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · P03950

Angiogenin

ANGI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P03950
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ANG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.27.-
Processing
Precursor
Secondary accessions
Q05CV1, Q53X86, Q6P5T2, Q8WXE7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Biological process

AngiogenesisDifferentiationStress response

Cellular component

CytoplasmNucleusSecreted

Molecular function

Developmental proteinDNA-bindingEndonucleaseHydrolaseNucleaseProtein synthesis inhibitor

PTM

Disulfide bondPyrrolidone carboxylic acid

Domain

Signal

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