Angiotensin Converting Enzyme Antibody / ACE

• Description:

  This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

• Specifications:

  ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL

• UniProt:

  P12821

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Full-length recombinant human protein was used as the immunogen for the Angiotensin Converting Enzyme antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  ACE/3764

• Applications:

  ELISA, IHC-P

• Purity:

  Protein A/G affinity

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Reconstitution:

  Aliquot the Angiotensin Converting Enzyme antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This Angiotensin Converting Enzyme antibody is available for research use only.

• Storage Conditions:

  Aliquot the Angiotensin Converting Enzyme antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

• Applications Notes:

  Optimal dilution of the Angiotensin Converting Enzyme antibody should be determined by the researcher.

• CAS Number:

  9007-83-4

• Location:

  Cell Surface

• Image Legend:

  IHC staining of FFPE human colon carcinoma tissue with Angiotensin Converting Enzyme antibody (clone ACE/3764) at 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.