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ABCG5 Antibody

CAT: 0800-R32320Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32320Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABCG5 (Atp-binding cassette, subfamily g, member 5) also known as STEROLIN 1, is a protein that in humans is encoded by the ABCG5 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. The ABCG5 gene contains 13 exons and spans about 28 kb. The ABCG5 gene is mapped on 2p21. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. Small (2003) reviewed the role of ABC transporters in secretion of cholesterol from liver into bile, particularly the role of ABCG5/ABCG8. The ABCG5 and ABCG8 genes are an example of closely neighboring genes in a head-to-head orientation that, when mutated, cause the same phenotype.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
Q9H222
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids ERRRVSIAAQLLQDPKVMLFDEPTT of human ABCG5 were used as the immunogen for the ABCG5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the ABCG5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ABCG5 antibody is available for research use only.
Storage Conditions
After reconstitution, the ABCG5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ABCG5 antibody should be determined by the researcher.
Location
Membrane
Image Legend
Western blot testing of human 1) MCF7, 2) A549 and 3) PANC lysate with ABCG5 antibody. Expected/observed molecular weight ~73 kDa.
Product Datasheet
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