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GAD67 Antibody

CAT: 0800-R31597Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31597Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glutamate decarboxylase 1 (GAD67), also known as GAD1, is a human gene. This gene encodes one of several forms of glutamic acid decarboxylase identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this GAD67 has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. It may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Human partial recombinant protein (AA 14-122) was used as the immunogen for this GAD67 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the GAD67 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This GAD67 antibody is available for research use only.
Storage Conditions
After reconstitution, the GAD67 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the GAD67 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of GAD67 antibody and Lane 1: rat testis; 2: mouse brain; 3: human MCF7 lysate. Predicted/observed molecular weight ~67 kDa

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